性能参数

产品名称

Pyrogallol

规格

10mM*1mLinDMSO 1g

货号

GOY-Y3301

 含量

>99.00%

CAS

87-66-1

别名

N/A

化学名

N/A

分子式

C6H6O3

分子量

分子量 126.11

溶解度

DMSO : ≥ 100 mg/mL (792.96 mM);H2O : 50 mg/mL (396.48 mM)

储存条件

Store at RT

General tips

用途

仅供科研

价格

电询

详细内容

Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.

Pyrogallol (PG) is a reductant that is able to generate free radicals, in particular superoxide anions (O2?-), so has frequently been used as a photographic developing agent and in the hair dying industry. Pyrogallol inhibits Calu-6 and A549 lung cancer cell growth via apoptosis and depletion of glutathione (GSH). Pyrogallol (PG) induces apoptosis in lung cancer cells via the overproduction of O2?- and affects mitogen activated protein kinases (MAPKs) in these cells[1]. The effect of Pyrogallol on human pulmonary fibroblast (HPF) cell viability and necrotic cell death is examined. For these experiments, 0, 50 or 100 μM Pyrogallol is used to differentiate the levels of cell viability inhibition or death with or without a given MAPK inhibitor. Treatment with 50 and 100 μM Pyrogallol decreases HPF viability by ~40 and 65% at 24 h, respectively. Treatment with an MEK inhibitor slightly enhances the inhibition of cell viability in 50 μM Pyrogallol-treated HPF cells, whereas treatment with a p38 inhibitor mildly attenuates the inhibition of viability. In 100 μM Pyrogallol-treated HPF cells, all the MAPK inhibitors increase the inhibition of viability to a certain extent, with treatment with the p38 inhibitor alone augmenting HPF control cell viability. Necrotic cell death is determined by measuring lactate dehydrogenase (LDH) release from cells. While treatment with 50 μM Pyrogallol does not affect LDH release from HPF cells, 100 μM Pyrogallol significantly increases LDH release[1].

盐酸甲胺  593-51-5  吡咯烷-3-甲酸  59378-87-9

1-Boc-3-吡咯烷甲醛  59379-02-1  **胺盐酸盐  593-81-7

2-甲基-3-硝基苯甲酸甲酯  59382-59-1  **基膦  594-09-2

3-氯-2-硝基苯胺  59483-54-4  DL-蛋氨酸  59-51-8

1-甲基吡唑-4-甲酸  5952-92-1  二甲基丙二酸  595-46-0

4-溴-2-甲氧基苯胺  59557-91-4  3-氨基-2-萘甲酸  5959-52-4

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