性能参数

产品名称

Meisoindigo

规格

5mg 10mg 50mg 100mg

货号

GOY-Y3221

 含量

>98.00%

CAS

97207-47-1

别名

化学名

(3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one

分子式

C17H12N2O2

分子量

分子量 276.29

溶解度

DMF: 16 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: 1 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Meisoindigo is a potential agent for acute myeloid leukemia [1].

Meisoindigo is a synthetic modification of indirubin. It has been used for chronic myeloid leukemia in China with less toxicity. In the in vitro assay, it can inhibit synthesis of DNA and RNA and the assembly of microtubules. It is also reported to have efficacy in acute myeloid leukemia. In the AML cell lines, HL-60, NB4 and U937, meisoindigo induces apoptosis in both caspase-dependent and -independent pathways. The effect induced by meisoindigo is likely mediated through the intrinsic mitochondrial pathway. Meisoindigo also induces cell cycle arrest with more cells in sub-G1 and G0/G1 phases and fewer cells in the S phase. Besides, meisoindigo is found to induce differentiation in HL-60 and NB4 cell lines. The expression of hTERT can be down-regulated by meisoindigo, which can enhance the anti-leukemic activity of chemotherapeutic agents. Moreover, meisoindigo shows a moderate anti-tumor efficacy in NOD/SCID mice injected with AML cells [1].

聚乙二醇二甲醚  24991-55-7  1-甲基-1H-吡唑-4-甲醛  25016-11-9

对氯苯乙酰氯  25026-34-0  7-羟基-5-甲基-1,3,4-三氮吲哚利嗪  2503-56-2

4-乙炔基吡啶  2510-22-7  3-乙炔基吡啶  2510-23-8

3,5-二甲基异噁唑-4-羧酸  2510-36-3  4-溴-3-氯苯甲酸,97%  25118-59-6

(R)-3-哌甲酸乙酯  25137-01-3  N-甲基邻苯二胺盐酸盐  25148-68-9

十二烷基苯磺酸钠?

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