性能参数

产品名称

TTNPB (Arotinoid Acid)

规格

10mM (in 1mL DMSO) 10mg 50mg

货号

GOY-Y3213

 含量

>98.00%

CAS

71441-28-6

别名

化学名

4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid

分子式

C24H28O2

分子量

分子量 348.48

溶解度

≥ 17.4mg/mL in DMSO

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

TTNPB (Arotinoid Acid) is an agonist of RAR with IC50 values of 3.8nM, 4nM and 4.5nM for RARα, RARβ and RARγ, respectively [1].

TTNPB is a teratogen with 1000-fold higher potency than tRA. TTNPB inhibits chondrogenesis with IC50 value of 0.14nM when using mouse limb bud cell cultures. The action of TTNPB results from binding to nuclear receptors. TTNPB can competes with [3H]tRA and prevent them from binding to mRARα, mRARβ and mRARγ with IC50 values of 3.8nM, 4nM and 4.5nM, respectively. Besides that, TTNPB also directly binds to mRARs with high potency. The Kd values are 2.5nM, 2.7nM and 1.8nM for mRARα, mRARβ and mRARγ, respectively. Moreover, TTNPB is reported to bind to mCRABPI and mCRABPII with 27-fold and 3.5-fold lower affinity than tRA [1].

4,6-二甲基-2-巯基嘧啶  22325-27-5  2,4-二氯苯乙酮  2234-16-4

(R)-(+)-alpha,alpha-二苯基脯氨醇  22348-32-9  月桂醇硫酸酯铵盐  2235-54-3

4-甲氧基水杨酸  2237-36-7  1-甲基-3-苯基丙胺  22374-89-6

3,3,3-三氟丙-1-醇  2240-88-2  人参皂苷 Rg1  22427-39-0

1,5-萘二胺  2243-62-1  山梨酸  22500-92-1

2-氯-5-甲基嘧啶  22536-?

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Netupitant D6 (CID-6451149 D6)1mg 5mg 10mg>98.00%Cas No. N/AC30H26D6F6N4O

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