性能参数

产品名称

Spautin-1

规格

10mM (in 1mL DMSO) 10mg 50mg

货号

GOY-Y3210

 含量

>98.00%

CAS

1262888-28-7

别名

化学名

(Z)-1-(4-fluorophenyl)-N-(6-fluoroquinazolin-4(3H)-ylidene)methanamine

分子式

C15H11F2N3

分子量

分子量 271.26

溶解度

≥ 13.5mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Description:

IC50: 0.6 and 0.7 μM for USP10 and USP13 activity, respectively

Autophagy is an important intracellular catabolic mechanism which mediates the degradation of cytoplasmic proteins and organelles. USP10 mediates the deubiquitination of p53, regulating deubiquitination the activities of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Spautin-1 is a novel autophagy inhibitor.

In vitro: Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes via inhibiting two ubiquitinspecific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 had no effect on the growth and survival of Bcap-37 cells under normal culture conditions but dramatically enhanced cell death in glucose-free media. Under glucose-free conditions, western blotting for LC3 further confirmed that autophagy was induced, which was inhibited by spautin-1. Similar results were obtained with MCF-7 and BT549 cells. Therefore, spautin-1 can sensitize tumor cells to apoptosis under nutritional deprived conditions [1].

In vivo: So far, there is no report to investigate the in vivo animal efficacy of spautin-1.

Clinical trial: Up to now, spautin-1 is still in the preclinical development stage.

2-氟-5-甲?；诫? 218301-22-5  3-氟-4-硝基苯腈  218632-01-0

5-苄硫基四氮唑  21871-47-6  2-羟基-3-硝基-4-甲基吡啶  21901-18-8

2-氨基-4-甲基-5-硝基吡啶  21901-40-6  2-基丙酮  21906-31-0

盐酸羟嗪  2192-20-3  4-[4-氯-3-(三氟甲基)苯基]-4-哌醇  21928-50-7

3,4,5-三氯溴苯  21928-51-8  3,5-二溴-2-羟基吡嗪  21943-15-7

?

Leucettine L411mg 5mg 10mg>98.00%Cas No. 1112978-84-3C17H13N3O3

Leteprinim (potassium salt)1mg 5mg 10mg>98.00%Cas No. 192564-13-9C15H12N5O4.K

Lumula1mg 5mg 10mg>98.00%Cas No. N/AC24H43NO4

Mesembrine1mg 5mg 10mg>98.00%Cas No. 24880-43-1C17H23NO3

Melanin Concentrating Hormone, salmon (MCH (salmon))500μg 1mg 5mg>98.00%Cas No. 87218-84-6C89H139N27O24S4

Medifoxamine5 mg 10 mg 25 mg>98.00%Cas No. 32359-34-5C16H19NO2

MCOPPB (hydrochloride hydrate)1 mg 5 mg 10 mg>98.00%Cas No. N/AC26H40N4·3HCl [XH2O]