性能参数

产品名称

Plumbagin

规格

10mM (in 1mL DMSO) 5 mg 25 mg

货号

GOY-Y3196

 含量

>98.00%

CAS

481-42-5

别名

化学名

5-hydroxy-2-methylnaphthalene-1,4-dione

分子式

C11H8O3

分子量

分子量 188.18

溶解度

≥ 6.35mg/mL in DMSO, ≥ 25.75 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

IC50: 11.69 μM for A549 cells

Plumbagin, a quinonoid constituent isolated from the root of Plumbago zeylanica L., has been shown to exert anticarcinogenic, antiatherosclerotic, and antimicrobial effects.

In vitro: Plumbagin exhibited effective cell growth inhibition via inducing cancer cells to undergo G2/M phase arrest and apoptosis. Blockade of cell cycle was associated with increased levels of p21 and reduced amounts of Cdc2, Cdc25C and cyclinB1. Plumbagin treatment also found to enhance the levels of inactivated phosphorylated Cdc2 and Cdc25C. Blockade of p53 activity partially decreased plumbagin-induced apoptosis and G2/M arrest, indicating it might be operated by p53-dependent and independent pathway [1].

In vivo: To determine whether plumbagin inhibited the in vivo tumor growth, A549 cells were injected into nude mice. Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/day, where around 80% reductions in tumor size were observed, in contrast with mice treated with the vehicle. No sign of toxicity was observed in plumbagin-treated mice as judged by monitoring body weight [1].

Clinical trial: N/A

2-溴-6-三氟甲基吡啶  189278-27-1  1-Boc-4-甲基-4-哌甲酸  189321-63-9

BOC-D-苯丙氨酸  18942-49-9  3-氟--5-甲基苯甲醛  189628-39-5

2-溴苄醇  18982-54-2  A,A二苯基Β苦基肼基游离基  1898-66-4

无水柠檬酸单钠盐  18996-35-5  N-甲基-3-氨基吡唑  1904-31-0

2,6-二氨基嘌呤  1904-98-9  4-溴-3-甲氧基苯胺  19056-40-7

3-溴-4-甲氧基苯胺?

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