性能参数

产品名称

Nutlin-3b

规格

5mg 10mg 50mg

货号

GOY-Y3187

 含量

>98.00%

CAS

675576-97-3

别名

化学名

4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

分子式

C30H30Cl2N4O4

分子量

分子量 581.49

溶解度

DMF: 14 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH7.2) (1:7): 0.12 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nutlin-3b is an inactive enantiomer of nutlin-3 [1].

Nutlin-3 is a small-molecule inhibitor of MDM2, interfering with MDM2-directedTP53 degradation. The stabilization of WT-TP53 leads to cell cycle arrest, growth inhibition, and apoptosis. As an inactive enantiomer, Nutlin-3b does not show any effect on the proliferation and has no insignificant effect on gene expression in cancer cells. Nutlin-3b binds MDM2 with about 200-fold lower affinity and is 150 times less active than 3a (an active enantiomer of nutlin-3). Nutlin-3b is usually used as a negative control. It shows no induction of MDM2, p53 or p21 expression and has no ability in colony-formation in H460 cell line. It also has no effect on cell cycle [1, 2].

4-硝基肉桂醛  1734-79-8  3-氯-2,4,5,6-四氟吡啶  1735-84-8

2-氯-4-羟基吡啶  17368-12-6  四氢噻喃-4-酮  17396-35-9

1,2-二甲基咪唑  1739-84-0  5-甲基吡啶-3-硼酸  173999-18-3

3,5-双三氟甲基苯乙酰氯  174083-39-7  2-氟-5-硝基苯腈  17417-09-3

4-羟基环己烷甲酸  17419-81-7  2-氰基-4-硝基苯胺  17420-30-3

2-溴-5-氯苯甲醛  17426?

Geissoschizine methyl ether1mg 5mg>98.00%Cas No. 60314-89-8C22H26N2O3

GBR 13069 dihydrochloride10mg 50mg>98.00%Cas No. 67469-45-8C28H30F2N2O.2HCl

GBR 12783 dihydrochloride10mg 50mg>98.00%Cas No. 67469-75-4C28H32N2O.2HCl

GAT2111mg 5mg>98.00%Cas No. 102704-40-5C22H18N2O2

Gap191mg 5mg>98.00%Cas No. 1507930-57-5C55H96N14O13

Ganglioside GT1b Mixture (sodium salt)1mg 5mg>98.00%Cas No. 59247-13-1C95H162N5O47?3Na

Glutaminyl Cyclase Inhibitor 2250mg 500mg>98.00%Cas No. 1884546-29-5C19H20FN3