性能参数

产品名称

Mdivi 1

规格

10mM (in 1mL DMSO) 10mg 50mg

货号

GOY-Y3176

 含量

>98.00%

CAS

338967-87-6

别名

化学名

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one

分子式

C15H10Cl2N2O2S

分子量

分子量 353.22

溶解度

≥ 17.65mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1). DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission.

In vitro: The most efficacious inhibitor, mdivi-1 attenuates mitochondrial division in yeast and mammalian cells by selectively inhibiting the mitochondrial Drp1-mediated division dynamin. Mdivi-1 potently blocks Bid-activated Bax/Bak-dependent cytochrome c release from mitochondria [1].

In vivo: Mdivi-1 treatment blocked apoptotic cell death in ischemic retina, and significantly increased RGC survival at 2 weeks after ischemia. Moreover, Mdivi-1 treatment did not change this increase of Drp1 protein expression but significantly decreased GFAP protein expression [2].

Clinical trial: Currently no clinical data are available.

2-氨基-3-氰基-5-甲基噻吩  138564-58-6  4-氧代-1,4-二氢-2,6-吡啶二甲酸  138-60-3

1-乙酰哌嗪  13889-98-0  十二烷基二甲基苄基氯化铵  139-07-1

2,4-二氟笨磺酰氯  13918-92-8  1-萘硼酸  13922-41-3

5-羟基吡嗪-2-羧酸甲酯  13924-95-3  Fmoc-L-赖氨酸盐酸盐  139262-23-0

4-三氟甲氧基苯硼酸  139301-27-2  2-溴-5-氰基吡啶  139585-70-9

3-溴异?

Diallyl Disulfide100mg 500mg 1g>90.00%Cas No. 2179-57-9C6H10S2

Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin (human))500μg 1mg 5mg>97.00%Cas No. 159899-65-7C159H252N46O48

Ac2-26 (human) (ammonium salt)1 mg 5 mg 10 mg 25 mg>90.00%Cas No. N/AC141H210N32O44S·NH4

Purity: >98.00%

EsculentosideA20mg>98.00%Cas No. 65497-07-6C42H66O16

Eprazinone 2HCl50mg>98.00%Cas No. 10402-53-6C24H32N2O2.2HCl

Ethyl LipotF10mg>98.00%Cas No. 1808089-27-1C19H19N3O4