性能参数

产品名称

Toremifene Citrate

规格

10mM (in 1mL DMSO) 100mg

货号

GOY-Y3161

 含量

>98.00%

CAS

89778-27-8

别名

化学名

2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid

分子式

C32H36ClNO8

分子量

分子量 598.08

溶解度

≥ 24.15mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Toremifene Citrate(NK 622; FC 1157a) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.IC50 Value: 1±0.3 μMTarget: Estrogen receptorToremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis and other adverse effects resulting from ADT in men with prostate cancer [1]. in vitro: The growth of Ac-1 cells was inhibited by tamoxifen, toremifene and atamestane in vitro with IC50values of 1.8±1.3μM, 1±0.3μM and 60.4±17.2μM, respectively. The combination of toremifene plusatamestane was found to be better than toremifene or atamestane alone in vitro[2].in vivo: The effect of this combination was then studied in vivo using Ac-1 xenografts grown in ovariectomized female SCID mice. The mice were injected with toremifene (1000μg/day), atamestane (1000μg/day), tamoxifen (100μg/day), or the combination of toremifene plus atamestane. In this study, our results indicate that the combination of toremifene plus atamestane was as effective as toremifene or tamoxifen alone but may not provide any additional benefit over toremifene alone or tamoxifen alone[2].Clinical trail: Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene[3].

香草酸  121-34-6  二环庚二烯  121-46-0

3-氨基苯磺酸  121-47-1  N-Boc-N-甲基乙二胺  121492-06-6

对氯甲基苯甲酸叔丁酯  121579-86-0  2-氨基-5-硝基噻唑  121-66-4

2-氯-4-硝基甲苯  121-86-8  2-氯-4-硝基苯胺  121-87-9

碘  12190-71-5  甲氨基乙醛缩二甲醇  122-07-6

BOC-DAP(FMOC)-OH  122235-70-5  氢氧化钡(八水)  12230-71-6

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