性能参数

产品名称

Tos-Arg-OMe.HCl

规格

Tos-Arg-OMe·HCl 25g Tos-Arg-OMe·HCl 100g

货号

GOY-Y3160

 含量

>98.00%

CAS

1784-03-8

别名

化学名

methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate;hydrochloride

分子式

C14H22N4O4S.HCl

分子量

分子量 378.9

溶解度

DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml

储存条件

General tips

用途

仅供科研

价格

电询

详细内容

TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest[1].

The absence of APC substrates, TAME hydrochloride ejects Cdc20 from the APC by promoting Cdc20 auto-ubiquitination in its N-terminal region. Cyclin B1 antagonizes TAME hydrochloride's effect by promoting binding of free Cdc20 to the APC and suppressing Cdc20 auto-ubiquitination[2]. TAME hydrochloride stabilizes cyclin B1 in Xenopus extract by two mechanisms. First, it reduces the kcat of the APCCdc20/cyclin B1 complex without affecting the Km, slowing the initial ubiquitination of unmodified cyclin B1. Second, as cyclin B1 becomes ubiquitinated, it loses its ability to promote Cdc20 binding to the APC in the presence of TAME hydrochloride. As a result, cyclin B1 ubiquitination terminates before reaching the threshold necessary for proteolysis[2].

N,N-二乙基-4-氨基苯甲醛  120-21-8  托品醇  120-29-6

N-哌嗪甲酸乙酯  120-43-4  钼酸铵  12054-85-2

氧化钆  12064-62-9  2-甲氧基-5-甲基苯胺  120-71-8

(1,5-环辛二烯)氯铑(I)二聚体  12092-47-6  二茂铁甲醛  12093-10-6

1-甲基吡咯烷  120-94-5  1,5-环辛二烯氯化铱二聚体  12112-67-3

CBZ-甘氨酸甲酯  1212-53-9  乙基香兰素  121-32-4

BINA5mg 10mg 25mg>99.00%Cas No. 866823-73-6C30H30O4

Bupivacaine-d9500 μg 1 mg 5 mg>99.00%Cas No. 474668-57-0C18H19D9N2O

Clozapine-d450 μg 100 μg 500 μg>99.00%Cas No. 204395-52-8C18H15D4ClN4

Decanoic Acid-d310mg 50mg 100mg>99.00%Cas No. 102611-15-4C10H17D3O2

Decanoic Acid-d210mg 50mg 100mg>99.00%Cas No. 62716-49-8C10H18D2O2

Dolasetron Mesylate hydrate10mM*1mLinDMSO 100mg 200mg>99.00%Cas No. 878143-33-0C20H26N2O7S

Diphenylpyraline HCl10mM (in 1mL DMSO) 500mg 1g>99.00%Cas No. 132-18-3C19H23NO.HCl