性能参数

产品名称

Z-VAD-FMK

规格

10mM (in 1mL DMSO) 1mg 5mg 10mg 25mg

货号

GOY-Y3076

 含量

>98.00%

CAS

187389-52-2

别名

Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone,Z-Val-Ala-Asp(OMe)-FMK

化学名

methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate

分子式

C22H30FN3O7

分子量

分子量 467.49

溶解度

≥ 23.37mg/mL in DMSO

储存条件

4°C, away from moisture and light

General tips

用途

仅供科研

价格

电询

详细内容

Z-VAD-FMK, an inhibitor of ICE-like proteases, inhibits apoptosis in THP.1 cells induced by diverse stimuli1 and Fas antigen-induced apoptosis in Jurkat T-cells2. It inhibits apoptosis by blocking the activation of proCPP32 into its active form, rather than by preventing the proteolytic action of CPP32 directly.

Z- VAD-FMK inhibits the formation of large kilobasepair fragments of DNA induced by diverse stimuli. Z-VAD-FMK had little or no effect on STS-induced necrotic cell death suggesting that the ICE-like protease activity was not involved in necrosis3.

Z-VAD-FMK almost completely inhibited the formation of large kilobasepair induced by all four stimuli. Similarly Z-VAD-FMK almost completely inhibited the enhanced formation of large kilobasepair fragments induced by thapsigargin or cycloheximide in the presence of TLCK, in good agreement with its ability to inhibit apoptosis induced by these treatments. These stimuli also induced internucleosomal cleavage of DNA, which was inhibited by Z-VAD-FMK. These results suggested that an ICE-like protease(s) acts at a stage prior to the formation of large kilobasepair fragments of DNA3.

环戊甲酸 99%   甲基硫酸新斯的明 98%

3-氯过氧苯甲酸 75%  正丙醇锆 70 wt. % 正丙醇溶液

甲基丙烯酸异冰片酯 85-90%,含150-200 ppm MEHQ稳定剂  色醇 97%(GC)

3-氯丙炔 99%  2-溴-5-甲氧基甲苯 98%

二苯甲胺 97%  二氧化硅 99.99% metals basis,粒径:5μm

3-羧基苯甲醛 97%  二氧化硅 99.99% metals basis,粒径:10μm

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