性能参数

产品名称

Tomivosertib

规格

1mg 5mg 10mg 50mg 100mg

货号

GOY-Y3060

 含量

>98.00%

CAS

1849590-01-7

别名

N/A

化学名

N/A

分子式

C17H20N6O2

分子量

分子量 340.38

溶解度

DMSO : 4.35 mg/mL (12.78 mM);H2O : < 0.1 mg/mL (insoluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms.

eFT508 reduces eIF4E phosphorylation dose-dependently at serine 209 (IC50=2-16 nM) in tumor cell lines. In a panel of appr 50 hematological cancers, eFT508 shows anti-proliferative activity against multiple DLBCL cell lines. Sensitivity to eFT508 in TMD8, OCI-Ly3 and HBL1 DLBCL cell lines is associated with dose-dependent decreases in production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10. Further evaluation eFT508 mechanism of action demonstrates that decreased TNFα production correlates with a 2-fold decrease in TNFα mRNA half-life[1].

eFT508 shows significant anti-tumor activity in the TMD8 and HBL-1 ABC-DLBCL models, both of which harbor activating MyD88 mutations. Besides, eFT508 combines effectively with components of R-CHOP and with novel targeted agents, including ibrutinib and venetoclax, in human lymphoma models[1].

浓馥香兰素 98%  二硅化钽 粉末,99.99% metals basis

乙基环戊烯醇酮 98%  硫化钽 99.8% metals basis

2-乙基呋喃 99%  氧化钨(IV) -100目,99.99% metals basis

愈创木油   钒粉 99.9% metals basis,100-200 mesh

3,4-己二酮 96%  五氧化二钒 AR,99.0%（剧毒品）

3,4-己二酮 96%,FCC  五氧化二钒 CP,99.0%（剧毒品）

TPMPA1mg 5mg 10mg 25mg>95.00%Cas No. 182485-36-5C6H12NO2P

Valnoctamide5mg 10mg 25mg 100mg>95.00%Cas No. 4171-13-5C8H17NO

Vigabatrin10mM*1mL in Water 5mg 50mg 100mg>95.00%Cas No. 68506-86-5C6H11NO2

Purity:

Quin-2 (potassium salt)5mg>90.00%Cas No. 73630-23-6C26H23N3O10?4K

Rhod-FF (potassium salt)50μg>90.00%Cas No. N/AC39H35F2N4O11?3K

Rhod-5N AM1mg>90.00%Cas No. N/AC51H56N5O11?Br