性能参数

产品名称

SKI II

规格

10mM (in 1mL DMSO) 25mg 100mg 500mg 1g

货号

GOY-Y3051

 含量

>98.00%

CAS

312636-16-1

别名

N/A

化学名

4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol

分子式

C15H11ClN2OS

分子量

分子量 302.78

溶解度

≥ 15.15mg/mL in DMSO

储存条件

Store at -20° C

General tips

用途

仅供科研

价格

电询

详细内容

SKI II is an inhibitor of sphingosine kinase with IC50 value of 0.5μM[1].

SKI II is selective against SK and has no inhibition of human protein kinases ERK2, PKC-I and the lipid kinase PI3K. It is reported that SKI II is not a competitive inhibitor at the ATP-binding site of SK. SKI II also inhibits endogenous SK in intact MDA-MB-231 cells [1].

As a SK inhibitor, SKI II prevents SK from catalyzing the generation of sphingosine 1-phosphate (S1P). The blockage of S1P formation leads to inhibition of proliferation, as well as the induction of apoptosis in cancer cells. SKI II shows cytotoxicity in T-24 human bladder carcinoma cells, MCF-7 human breast adenocarcinoma cells and the subline of MCF-7 cells, MCF-7/VP, with IC50 values of 4.6μM, 1.2μM and 0.9μM, respectively [1].

1,5-二氮杂双环[4.3.0]-5-壬烯 98%  氧化钐 99.999% metals basis

1,4-二氯-2-丁炔 97%  锆酸锶 -325目粉,99.0% metals basis

2-氯乙醛缩二甲醇 98%  氯化铽,六水 99.9% metals basis

2-乙氧基苯胺 98%  氯化铽,六水 99.999% metals basis

双组份无吡啶滴定剂 5mg水/ml,测含水量较高样品。 2瓶500毫升为  氧化钛(IV)，锐钛矿 99.9% metals basis，粉末

双组

PF-012473245mg 10mg 25mg 50mg 100mg>98.00%Cas No. 875051-72-2C13H10Cl3N3O

Pipequaline (PK-8165)2mg 5mg 10mg 50mg 100mg>9

Pozanicline dihydrochloride1mg 5mg 10mg 50mg 100mg>98.00%Cas No. 161416-61-1C11H18Cl2N2O

Pirmenol hydrochloride (Cl-845)1mg 5mg 10mg 50mg 100mg>98.00%Cas No. 61477-94-9C22H31ClN2O

PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine)5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 55476-47-6C19H15NO3S

Raxatrigine hydrochloride (GSK-1014802 hydrochloride)2mg 5mg 10mg 50mg 100mg>98.00%Cas No. 934240-31-0C18H20ClFN2O2