性能参数

产品名称

Roquinimex

规格

10mM*1mL in DMSO 10mg 50mg 100mg 200mg

货号

GOY-Y3041

 含量

>98.00%

CAS

84088-42-6

别名

N/A

化学名

N/A

分子式

C18H16N2O3

分子量

分子量 308.33

溶解度

DMSO: ≥ 83.3 mg/mL (270.17 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.IC50 value:Target: TNF alphaProphylactic administration of DSS-treated mice with roquinimex significantly reduced clinical signs of colitis, MDS and the CH-reduction. Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice. Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity [2]. Linomide, a synthetic immunomodulator, at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS patients' blood when analysed in vitro. Compared to dexamethasone, Linomide up-regulated levels of blood MNC expressing mRNA of TGF-beta after culture in presence of MBP [3].

[1]. Roquinimex, From Wikipedia [2]. Liu Q, et al. Roquinimex inhibits dextran sodium sulfate-induced murine colitis. Inflamm Res. 2003 Feb;52(2):64-8. [3]. Tian WZ, et al. Linomide (roquinimex) affects the balance between pro- and anti-inflammatory cytokines in vitro in multiple sclerosis. Acta Neurol Scand. 1998 Aug;98(2):94-101.

乙基纤维素 6-9mPa.s, 5%甲苯/异丙醇80:20  气相纳米二氧化硅 99.8%,比表面积（BET）：170m2/g；粒径：7-40n

乙基纤维素 9-11mPa.s, 5%甲苯/异丙醇80:20  气相纳米二氧化硅 99.8%,比表面积（BET）：120m2/g；粒径：7-40n

乙基纤维素 18-22mPa.s, 5%甲苯/异丙醇80:20  疏水气相纳米二氧化硅 99.8%,比表面积(BET):230m2/g;;粒径:7-40n

乙基纤维素 45-55mPa.s, 5%甲苯/异丙醇80:2

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