RAD51 Inhibitor B02
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产品名称:
RAD51 Inhibitor B02
产品型号:
GOY-Y3030
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-04
简单介绍
RAD51 Inhibitor B02DMSO : ≥ 37 mg/mL (109.02 mM)
RAD51 Inhibitor B02
的详细介绍
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性能参数
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产品名称
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RAD51 Inhibitor B02
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规格
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5mg 10mg 25mg 50mg 100mg
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货号
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GOY-Y3030
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含量
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>98.00%
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CAS
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1290541-46-6
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别名
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N/A
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化学名
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N/A
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分子式
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C22H17N3O
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分子量
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分子量 339.39
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溶解度
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DMSO : ≥ 37 mg/mL (109.02 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 uM.
RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 uM), but not its E. coli homologue RecA (IC50>250 uM)[1]. The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231[2].
B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo. B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth[2].
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