性能参数

产品名称

Puromycin aminonucleoside

规格

10mM (in 1mL DMSO) 50mg 250mg 500mg 1g

货号

GOY-Y3029

 含量

>98.00%

CAS

58-60-6

别名

3'-Amino-3'-deoxy-N6,N6-dimethyladenosine

化学名

4-amino-2-[6-(dimethylamino)purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol

分子式

C12H18N6O3

分子量

分子量 294.31

溶解度

≥ 14.45 mg/mL in DMSO, ≥ 29.4 mg/mL in EtOH with gentle warming, ≥ 29.5 mg/mL in H2O with gentle warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

IC50: N/A

Puromycin aminonucleoside, 3'-Amino-3'-deoxy-N6,N6-dimethyladenosine, is the aminonucleoside portion of the antibiotic puromycin. Puromycin aminonucleoside (PAN)-induced nephrosis in rats can provide a model for investigating the pathogenesis of severe proteinuric conditions.

In vitro: A pervious study used scanning (SEM) and transmission (TEM) electron microscopy to test the in vitro effects of PAN on rat glomerular podocytes. Slices of rat kidney were incubated with PAN. SEM analysis of glomeruli on kidney slices indicated incubation with PAN decreased the number of microvilli on podocyte cell bodies and increased the number of glomeruli. TEM morphometry showed PAN incubation significantly retarded the loss of podocyte foot processes that was observed in control groups [1].

In vivo: In Wistar rats, multiple injections of PAN resulted in sustained severe proteinuria and FSGHS lesions of their glomeruli. In PVG/c rats, a higher PAN dose was needed to induce chronic proteinuria. In acute PAN nephrosis induced by a single intravenous injection of PAN the mesangium of Wistar rats showed large amounts of lipid in contrast to a few small mesangial lipid droplets in nephrotic PVG/c rats. Moreover, after injection of colloidal carbon in nephrotic PVG/c rats no enhanced carbon accumulation was found in the mesangium when compared to nonproteinuric controls [2].

Clinical trial: N/A

三氟乙酸甲酯 99%  三氧化钼 AR,99.5%

1,1,1-三氟-2-丁酮 96%  三氧化钼 SP,99.0%

三氟乙酸酐 98%  三氧化钼 99.95%，100nm

三氟乙酸酐（TFAH） 衍生级 (for GC), ≥99.0% (GC)  二硫化钼 AR,99%

1，1，1-三氟丙酮 97%  二硫化钼 99.5% metals basis,18000目

三氟乙酰胺 97%  锰粉 99.99% metals basis,粉末

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