性能参数

产品名称

Q-VD(OMe)-OPh

规格

10mM (in 1mL DMSO) 1mg 5mg 10mg 25mg

货号

GOY-Y3027

 含量

>98.00%

CAS

Cas No.

别名

Q-VD(OMe)-OPh

化学名

(S)-methyl 5-(2,6-difluorophenoxy)-3-((S)-3-methyl-2-(quinoline-2-carboxamido)butanamido)-4-oxopentanoate

分子式

C26H25F2N3O6

分子量

分子量 527

溶解度

≥ 26.35mg/mL in DMSO, ≥ 97.4 mg/mL in EtOH

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad spectrum caspase inhibitor,  provides a cost effective, non toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors. [1] It is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk. Q-VD-OPh is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase 12. In addition to the increased effectiveness, Q-VD-OPh was not toxic to cells, even at high concentrations. Q-VD-OPh is equally effective at inhibiting the three major apoptotic pathways, it can inhibit recombinant caspases 1, 3, 8, and 9 with IC50 values ranging from 25 to 400 nM2. The effectiveness of Q-VD-OPh as an apoptotic inhibitor is evidenced by the complete suppression of an apoptotic inducer capable of inducing substantial cell death in less than 4 hours. [2] Q-VD-OPh protected against the substantial apoptosis induced by actinomycin D. In addition, Q-VD-OPh alone exhibited little or no toxicity, even at extremely high concentrations.

甲壳素 生物试剂级，用于几丁质酶分析  氯化镥(III),六水 99.99% metals basis

氯二氟乙酸酐 98%  硫酸镥(III),八水 99.9% REO

二氟乙酸 98%  六硼化镧  粉末,-325目,99.5% metals basis

2,2-二氟乙醇 97%  二硅化钼 99.9%

1,1-二溴-3,3,3-三氟丙酮 95%  二硅化钼 99%

二氟乙酸乙酯 97%  氧化镁 AR,98.0%

ZK 93426 hydrochloride10mg 50mg>98.00%Cas No. 1216792-30-1C18H20N2O3.HCl

ZK 20077510mg 50mg>98.00%Cas No. 161605-73-8C14H15N3O6F3P

Zatebradine hydrochloride10mg 50mg>98.00%Cas No. 91940-87-3C26H36N2O5.HCl

ZAPA sulfate10mg 50mg>98.00%Cas No. 371962-01-5C4H6N2O2S.H2SO4

Z 94410 mg 50 mg>98.00%Cas No. 1199236-64-0C19H27ClFN3O2

PF-052413285mg 10mg 50mg>98.00%Cas No. 1387633-03-5C19H21ClN4O4S