性能参数

产品名称

PIM447

规格

1mg 5mg 10mg 50mg 100mg

货号

GOY-Y3018

 含量

>98.00%

CAS

1210608-43-7

别名

N/A

化学名

N/A

分子式

C24H23F3N4O

分子量

分子量 440.46

溶解度

DMSO : 33.33 mg/mL (64.92 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.target: pan-PIM inhibitor [2] [3]In vitro: PIM447 is cytotoxic for myeloma cells due to cell cycle disruption and induction of apoptosis mediated by a decrease in phospho-Bad (Ser112) and c-Myc levels and the inhibition of mTORC1 pathway. PIM447 also inhibits in vitro osteoclast formation and resorption, downregulates key molecules involved in these processes and partially disrupts the F-actin ring, while increasing osteoblast activity and mineralization.[1]In vivo: PIM447 significantly reduces the tumor burden and preventes tumor-associated bone loss in a disseminated murine model of human myeloma.[1]

1,2-二氢-2-异丁氧基喹啉-1-甲酸异丁酯 98%  纳米氧化钬 99.9% metals basis,<100 nm particle size (BET)

对苯二甲酸单甲酯 97%  氧化铪(IV)  99.99% metals basis

S-甲基-L-半胱氨酸亚砜 99%  钬锭 99.9% metals basis

1-(均**苯基-2-砜基)-3-硝基-1,2,4-三唑  99%  碳化铪 99.5%，Zr <1% ，325目

MEI  纯度≥98%  碳化铪 99.99% metals

Talniflumate10mg 50mg>98.00%Cas No. 66898-62-2C21H13F3N2O4

Synthalin sulfate10mg 50mg>98.00%Cas No. 182285-12-7C12H28N6.H2SO4

TCS 46b10mg 50mg>98.00%Cas No. 302799-86-6C22H23N3O

TCS 120550mg 10mg>98.00%Cas No. 355022-97-8C18H15N3O4

TCS 110510mg 50mg>98.00%Cas No. 185391-33-7C17H13FN2O2