性能参数

产品名称

PHA-767491 hydrochloride

规格

10mM*1mL in DMSO 10mg 50mg 100mg 200mg

货号

GOY-Y3017

 含量

>98.00%

CAS

942425-68-5

别名

N/A

化学名

N/A

分子式

C12H12ClN3O

分子量

分子量 249.7

溶解度

H2O: 50 mg/mL (200.24 mM); DMSO: 17.33 mg/mL (69.40 mM and warming)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. CDK9|34 nM (IC50)|CDK2|240 nM (IC50)|CDK1|250 nM (IC50)|CDK5|460 nM (IC50)|GSK3-β|220 nM (IC50)|Mk2|470 nM (IC50)|Plk1|980 nM (IC50)|Chk2|1100 nM (IC50)

PHA-767491 inhibits proliferation in both cell lines with an IC50 of 0.64 μM in HCC1954 cells and 1.3 μM in Colo-205 cells. PHA-767491 is effective DDK inhibitors in vitro, with IC50 values of 18.6 nM. PHA-767491 (2 μM) completely abolishes Mcm2 phosphorylation by 24 hours in HCC1954 cells[1]. PHA-767491 in combination with 5-FU exhibits much stronger cytotoxicity and induces significant apoptosis manifested by remarkably increased caspase 3 activation and poly(ADP-Ribose) polymerase fragmentation in HCC cells. PHA-767491 directly counteracts the 5-FU-induced phosphorylation of Chk1 and decreases the expression of the anti-apoptotic protein myeloid leukemia cell 1ine[2]. PHA-767491 (0-10 μM) decreases glioblastoma cell viability in a time- and dose-dependent fashion, with IC50 of approximately 2.5 μM for U87-MG and U251-MG cells. PHA-767491 hydrochloride induces apoptosis in glioblastoma cells, suppresses glioblastoma cell proliferation, cell migration and cell invasion[3].

PHA-767491 decreases Chk1 phosphorylation and increases in situ cell apoptosis in tumor tissues sectioned from nude mice HCC xenografts[2].

糠酰氯 97%  氧化锗 99.99% metals basis,200目

苯并三氮唑-N,N,N',N'-四甲基脲六氟磷酸酯 99%  硝酸钆,六水 AR，99%

3-羟基-1,2,3-苯并三嗪-4(3H)-酮 98%  硝酸钆,六水 99.99% metals basis

2-(7-偶氮苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯 99%  硝酸钆,六水 99.999% metals basis

1-羟基-7-偶氮苯并三氮唑 99%  氧化钬 99.99% metals basis

N-羟基-

Suramin hexasodium salt10mM (in 1mL DMSO) 25mg>98.00%Cas No. 129-46-4C51H34N6Na6O23S6

STF 3110mg 50mg>98.00%Cas No. 724741-75-7C23H25N3O3S

SSR 180711 hydrochloride10 mg 50 mg>98.00%Cas No. 446031-79-4C14H17BrN2O2.HCl

SR 1380010 mg 50 mg>98.00%Cas No. 227321-12-2C25H29N3O2S

SQ-31765 (SQ31765)5mg 10mg>98.00%Cas No. 138383-07-0C24H27F3N2O4

Tariquidar dihydrochloride10 mg 50 mg>98.00%Cas No. 1992047-62-7C38H38N4O6.2HCl