性能参数

产品名称

Nutlin-3

规格

0mM (in 1mL DMSO) 5mg 10mg 25mg 100mg

货号

GOY-Y3004

 含量

>98.00%

CAS

890090-75-2

别名

Nutlin 3,MDM2 Antagonist

化学名

4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

分子式

C30H30Cl2N4O4

分子量

分子量 581.5

溶解度

≥ 58.2 mg/mL in DMSO, ≥ 5.69 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nutlin-3, a tetra-substituted imidazoline, is a potent and selective small-molecule antagonist of murine double minute 2 (MDM2), which occupies the binding site of p53 in MDM2 and consequently prevent MDM2 binding to p53 leading to the disruption of the autoregulator feedback loop and the fostering of the p53 tumor suppressor network. It also binds to murine double minute 4 (MDM4), which is another component of the p35 tumor surveillance pathway. Nutlin-3 is being investigated as an antitumor agent for its antiangiogenic activity in cells through inhibiting endothelial cell migration, inducing cell cycle arrest, and increasing apoptotic tendency in endothelial cells.

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