性能参数

产品名称

Obatoclax mesylate 

规格

10mM (in 1mL DMSO) 5mg 10mg 25mg 50mg

货号

GOY-Y3002

 含量

>98.00%

CAS

803712-79-0

别名

N/A

化学名

(2Z)-2-[(5Z)-5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indole;methanesulfonic acid

分子式

C20H19N3O.CH4O3S

分子量

分子量 413.5

溶解度

≥ 20.7 mg/mL in DMSO, ≥ 3.15 mg/mL in EtOH with ultrasonic and warming

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

Obatoclax mesylate, also known as GX15-070, is a hydrophobic small molecule that potently inhibits BCL-2 family by binding to the BH3-binding site of BCL-2 and other related BCL-2 family members (including BCL-XL, MCL-1, A1, and BCL-B).  As a pan-BCL-2 inhibitor being investigated for the treatment of refractory malignancies, obatoclax mesylate directly induce apoptosis in cultured acute myeloid leukemia (AML) cells as well as primary patient samples and exhibits antitumor activity in mouse xengografts of solid tumor and myeloma cell lines. Study results have shown that obatoclax mesylate inhibited clonogenic growth of primary AML samples (IC50 < nmol/L) and dissociated Bak and Bim from MCL-1 in cultured AML cells.

碘标准溶液 0.05000mol/L (0.1N)  碳酸铯 99.99% metals basis

2,6-二甲基吡啶 98%  碳酸铯 AR，99% metals basis

2,6-二甲基吡啶 分析标准品，≥99.5% (GC)  碳酸铯 99.9% metals basis

二氧化锰 CP,72%  锗粉 99.999% metals basis，1mm

3-甲氧基丙烯酸甲酯 95%  锗 Φ5mm 高2.5mm 锥形体 Ge≥99.999％

乙酰乙酸甲酯 GR，99.5%  锗粒 99.99%

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