性能参数

产品名称

MI-2

规格

10mM (in 1mL DMSO) 5mg 10mg 50mg 200mg

货号

GOY-Y2991

 含量

>98.00%

CAS

1271738-62-5

别名

Menin-MLL inhibitor 2;Thieno[2,3-d]pyrimidine, 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propyl-

化学名

4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine

分子式

C18H25N5S2

分子量

分子量 375.55

溶解度

≥ 15.1 mg/mL in DMSO, ≥ 46.4 mg/mL in EtOH with gentle warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

MI-2 is a Menin-MLL inhibitor with IC50 value of 0.45 μM [1].

Mixed-lineage leukemia (MLL) is a common target of chromosomal translocations in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The leukemogenic activity of MLL fusion proteins is dependent on their direct interaction with menin, which is a tumor suppressor that directly controls cell growth in endocrine organs [1].

MI-2 is a Menin-MLL inhibitor. MI-2 bound to the wild-type menin but didn’t bind M278K and Y323K menin mutants. In HEK293 cells transfected with Flag-MLL-AF9, MI-2 effectively inhibited the menin-MLL-AF9 interaction without affecting the expression level of menin and MLL-AF9. In mouse bone marrow cells (BMC) transduced with MLL-AF9 and MLL-ENL, MI-2 blocked proliferation of BMC with GI50 value of about 5 μM. Also, MI-2 inhibited colony formation in BMC transduced with MLL-AF9. In a series of human MLL leukemia cell lines, MI-2 significantly inhibited translocation in a dose dependant way [1].

甘草次酸(β型） 97%  砷  99.995% metals basis

冬凌草甲素 98%  砷标准溶液 浓度范围:0.444(mg/L) ±0.028mg/L

连翘脂素 分析标准品，>98%  溴化铝 98%

原花青素 分析标准品，UV≥95%  锑粉 99.5% metals basis

萝卜硫素 90%  锑 CP,99.0%

川楝素 分析标准品 ，≥98%  锑粒 99.999% metals basis,beads,1-6 mm

(R)-baclofen50mg 10mg0.9986Cas No. 69308-37-8C10H12ClNO2

Gadolinium chloride10mM (in 1mL DMSO) 50mg0.999Cas No. 10138-52-0GdCl3

Charybdotoxin TFA1 mg 5 mg 10 mg>96.00%Cas No. N/AC176H277N57O55S7.C2HF3O2

Caroverine hydrochloride10 mg 25 mg 50 mg 100 mg>96.00%Cas No. 55750-05-5C22H28ClN3O2

MK6-831mg 5mg 10mg 25mg>97.00%Cas No. 1062271-24-2C16H20N2O2S2

其它信号转导

Endothelin-1 (1-15), amide, human1mg>98.00%Cas No. N/AC70H109N17O23S5