性能参数

产品名称

Z-YVAD-FMK

规格

10mM (in 1mL DMSO) 1mg 5mg 10mg

货号

GOY-Y2983

 含量

>98.00%

CAS

210344-97-1

别名

N/A

化学名

(8S,11S,14S)-methyl 14-(2-fluoroacetyl)-5-(4-hydroxybenzyl)-8-isopropyl-11-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

分子式

C31H39FN4O9

分子量

分子量 630.7

溶解度

≥ 31.55mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.

In Caco-2 cells, Z-YVAD-FMK significantly decreased the growth inhibition induced by butyrate. Complete abrogation of butyrate’s effect occurred at an inhibitor concentration of 100 mol/L. It is indicated that caspase-1 inhibitor significantly alters the caspase cascade, diminishing the butyrate-induced apoptotic effect [1]. After treated with Alum reflected caspase-1 activation, IL-1-release in cells was blocked by Z-YVAD-FMK. This effect was observed even in MyD88-deficient bone marrow DC [2].

References:

1.Avivi-Green C, Polak-Charcon S, Madar Z, et al. Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J Nutr. 2002 Jul;132(7):1812-8.

2.Li H, Nookala S, Re F. Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J Immunol. 2007 Apr 15;178(8):5271-6.

N,N-二甲基苄胺 CP,98.0%  2-溴-4-甲基吡啶 97%

N,N-二甲基苄胺 99%  2-氯吡啶-3-硼酸 97%

用于蛋白测序分析, ≥99.5% (GC)  6-甲基-2-吡啶醛 98%

油酸钾 CP  5-甲氧基-3-吡啶甲醛 97%

N,N,N',N'',N''-五甲基二乙烯基三胺 99%  三氧化钨 99.99% metals basis

乙酸苯汞 98%（剧毒品）  三氧化钨 99.8% metals basis

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AC19035mg 10mg>95.00%Cas No. 831234-13-0C19H17N3O

Apoptolidin100μg 500μg>95.00%Cas No. 194874-06-1C58H96O21

CALP11mg 5mg>95.00%Cas No. 145224-99-3C40H75N9O10

Cypermethrin50 mg 100 mg>95.00%Cas No. 52315-07-8C22H19Cl2NO3

DNQX disodium salt10mg 50mg>95.00%Cas No. 1312992-24-7C8H2N4O6Na2