性能参数

产品名称

Z-Asp-CH2-DCB

规格

5mg 10mg 25mg 50mg

货号

GOY-Y2978

 含量

>98.00%

CAS

153088-73-4

别名

Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone

化学名

(3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester 2,6-dichloro-benzoic acid

分子式

C20H17Cl2NO7

分子量

分子量 454.3

溶解度

≤33mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Z-Asp-CH2-DCB is an inhibitor of ICE/Ced-3 family proteases [1].

Caspases (ICE/ Ced3 proteases) play key biological roles in inflammation and mammalian apoptosis. Caspases are a closely related family of cysteine proteases that play a key role in apoptotic cell death. Activation of Caspases shows important roles in programmed cell death such as pyroptosis and necroptosis to protect cells from stress signals and pathogenic attack. Caspases play an important role in inflammation. Caspases have also been involved in cell proliferation, cell differentiation, tumour suppression, neural development and axon guidance and ageing. Deficiency in caspase results in tumour development. Overactivation of some caspases can lead to excessive programmed cell death, such as caspase-3 [2].

Z-Asp-CH2-DCB blocked apoptosis in U937 cells triggered by antitumor agents. Z-Asp-CH2-DCB also blocked apoptosis in IFN-γ-pretreated cells. Z-Asp-CH2 -DCB completely inhibited DNA fragmentation induced by γ-irradiation, antitumor agents, or anti-Fas antibody [1].

硫化铜 AR,99.0%  锌粉 AR,99%

硫化铜 CP,98.0%  锌粉 SP

硫化铜 99.99%  硫酸氢铵 AR

乙酸锶 AR,99%  kerio mail邮箱服务器解决方案

乙酸锶 CP,98%  钛酸钡 粉末, <2 μm, 99.5% metals basis

赤磷 99.999%,块状1-5mm  钛酸钙 99.5% metals basis，粉末, 2 μm

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