Taltobulin hydrochloride (HTI-286 hydrochloride)
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产品名称:
Taltobulin hydrochloride (HTI-286 hydrochloride)
产品型号:
GOY-Y2952
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-04
简单介绍
Taltobulin hydrochloride (HTI-286 hydrochloride)DMSO : ≥ 100 mg/mL (196.04 mM)
Taltobulin hydrochloride (HTI-286 hydrochloride)
的详细介绍
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性能参数
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产品名称
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Taltobulin hydrochloride (HTI-286 hydrochloride)
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规格
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10mM*1mLinDMSO 5mg 10mg 50mg
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货号
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GOY-Y2952
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含量
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>98.00%
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CAS
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N/A
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别名
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N/A
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化学名
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N/A
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分子式
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C27H44ClN3O4
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分子量
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分子量 510.11
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溶解度
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DMSO : ≥ 100 mg/mL (196.04 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Taltobulin hydrochloride is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.IC50 value:Target: tubulinin vitro: HTI-286 significantly inhibits proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L). Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 is a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2].in vivo: Intravenous administration of HTI-286 significantly inhibits tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibits growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy is superior to sequential treatment in the LNCaP model [2].
[1]. Vashist YK, et al. Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin. World J Gastroenterol. 2006 Nov 14;12(42):6771-8. [2]. Hadaschik BA, et al. Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin. Int J Cancer. 2008 May 15;122(10):2368-76.
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