性能参数

产品名称

SLM6031434 (hydrochloride)

规格

5mg 10mg 25mg 50mg

货号

GOY-Y2944

 含量

>98.00%

CAS

1897379-34-8

别名

N/A

化学名

N/A

分子式

C22H30F3N5O2 ? HCl

分子量

分子量 490

溶解度

DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

SLM6031434 is an inhibitor of sphingosine kinase 2 (SPHK2) (Ki = 0.4 μM for the recombinant mouse enzyme).1 It is selective for SPHK2 over SPHK1 (Kis = >20 μM). It decreases sphingosine-1-phosphate and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice. SLM6031434 also increases blood S1P levels in wild-type mice and rats.

|1. Kharel, Y., Morris, E.A., Congdon, M.D., et al. Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J. Pharmacol. Exp. Ther. 355(1), 23-31 (2015).

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