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Se-Aspirin

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产品名称: Se-Aspirin
产品型号: GOY-Y2939
产品展商: 谷研
产品文档: 无相关文档
发布时间:2023-05-04

简单介绍

Se-Aspirin≤10mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide


Se-Aspirin  的详细介绍

性能参数

产品名称

Se-Aspirin

规格

1mg 5mg 10mg 50mg

货号

GOY-Y2939

 含量

>98.00%

CAS

1850293-95-6

别名

Selenium-acetylsalicylic Acid

 

 

化学名

selenocyanic acid, 2-[[2-(acetyloxy)benzoyl]amino]ethyl ester

分子式

C12H12N2O3Se

分子量

分子量 311.2

溶解度

≤10mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide

储存条件

Store at -20°C

General tips

 

用途

仅供科研

价格

电询

详细内容

Se-Aspirin is a novel selenium-nonsteroidal anti-inflammatory drug (Se-NSAID) [1].

NSAIDs have demonstrated intestinal antineoplastic effects in various animal intestinal cancer models. Selenium (Se) compounds have attracted a vast interest as promising chemo-preventive agents. Several epidemiological studies have reported an inverse association between the nutritional Se status and cancer risk. Se functioned as chemo-preventive agent for cancer therapy in the past few years.

Se-Aspirin was a hybrid of selenium and a nonsteroidal anti-inflammatory drug. t Se-Aspirin reduced the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells with the IC50 value of 3.4 μM. Se-Aspirin inhibited the cell cycle in G1 and G2/M phases and induced apoptosis by activating caspase 3/7 and PARP cleavage. Long-term exposure to Se-Aspirin has been reported to cause an increase in intracellular reactive oxygen species levels in CRC cells [1].

 

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