性能参数

产品名称

SGI-1776 free base

规格

10mM (in 1mL DMSO) 5mg 10mg 50mg

货号

GOY-Y2937

 含量

>98.00%

CAS

1025065-69-3

别名

SGI1776,SGI 1776

化学名

N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine

分子式

C20H22F3N5O

分子量

分子量 405.42

溶解度

≥ 40.5 mg/mL in DMSO, ≥ 101 mg/mL in EtOH

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. According to preliminary results from studies treating prostate cancer cells, SGI-1776 dose-dependently reduces phosphorylation of known Pim kinase substrates involved in cell cycle progression and apotosis (p21Cip1/WAF1 and Bad), compromises overall cell viability by inducing G1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (MDR1) protein based taxane-refractory prostate cancer cell line.

妥 AR,98.0%（剧毒品）  2-金刚烷胺盐酸 99%

妥 CP（剧毒品）  N-(β-氨乙基-γ-氨丙基)甲基二甲氧基硅烷  96%

溴酚蓝钠 AR  2-金刚烷醇 98%

刚果红 AR  1-金刚烷甲醇 99%

偶氮氯膦Ⅲ 显色剂  1-金刚烷醇 99%

变色酸2R AR  1-(1-金刚烷基)乙基胺盐酸盐 99%

Nicainoprol (RU-42924)10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. 76252-06-7C21H27N3O3

NHE3-IN-11mg 5mg 10mg>98.00%Cas No. 632355-6

Nisoldipine10mM (in 1mL DMSO) 200mg 500mg>98.00%Cas No. 63675-72-9C20H24N2O6

Nimodipine10mM (in 1mL DMSO) 100mg 1g>98.00%Cas No. 66085-59-4C21H26N2O7

Nilvadipine10mM (in 1mL DMSO) 10mg 50mg>98.00%Cas No. 75530-68-6C19H19N3O6

Nigericin sodium salt5mg 10mg 25mg>98.00%Cas No. 28643-80-3C40H67NaO11