性能参数

产品名称

Salinomycin

规格

10mM (in 1mL DMSO) 5mg 10mg 50mg

货号

GOY-Y2929

 含量

>98.00%

CAS

53003-10-4

别名

Procoxacin

化学名

Procoxacin

分子式

C42H70O11

分子量

分子量 751

溶解度

≥ 91.8 mg/mL in DMSO, ≥ 142.2 mg/mL in EtOH

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment)

Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, or other pathways.

In vitro: Several hepatocellular carcinoma (HCC) cell lines were treated with Sal. Results showed that Sal inhibited proliferation and decreased PCNA levels. Cell cycle analysis showed that Sal caused cell cycle arrest in different phases. Sal induced apoptosis as characterized by an increase in the Bax/Bcl-2 ratio. Compared to control, β-catenin expression was down-regulated by Sal treatment significantly. The Ca2+ concentration in HCC cells was examined by flow cytometry and it was found that higher Ca2+ concentrations were observed in Sal treatment groups [1].

In vivo: The in vivo anti-tumor effect of Sal was verified using the hepatoma orthotopic tumor model and results showed that the liver tumor size in Sal-treated groups decreased. Immunohistochemistry and TUNEL staining also demonstrated that Sal could in vivo inhibit proliferation and induced apoptosis [1].

Clinical trial: N/A

二氢香芹醇乙酸脂 98%  5,10,15,20-四(4-吡啶基)卟啉 97%

3,4-二甲基-1,2-环戊二酮 97%  3,4-乙烯二氧噻吩 99%

3，5-二甲基环戊烯醇酮 97%,FG  对甲苯磺酸钠 96%

2,5-二甲基-4-甲氧基-3(2H)-呋喃酮 97%  1-金刚烷甲酰氯 97%

突厥烯酮 1.1-1.3 wt. %,食品级  1-溴-3,4-(亚甲基二氧基)苯 97%

浓馥香兰素 98%  N-乙基顺丁烯二酰亚胺 99%

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