性能参数

产品名称

Pentagamavunon-1

规格

10mM*1 mL in DMSO 10mg 50mg 100mg

货号

GOY-Y2911

 含量

>98.00%

CAS

27060-70-4

别名

N/A

化学名

N/A

分子式

C23H24O3

分子量

分子量 348.43

溶解度

DMSO: 50 mg/mL (143.50 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation[1].

Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 μM) enhances cytotoxic effect of 5-FU on WiDr cells[1].Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 μM) shows different effects on cell cycle progression and induces G2/M arrest[1]. Cell Viability Assay[1]. Cell Line: Human colon carcinoma WiDr.

Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity[1]. Animal Model: Human cancer cells in a xenograf mouse model[2].

[1]. Edy Meiyanto, et al. Curcumin Analog Pentagamavunon-1 (PGV-1) Sensitizes Widr Cells to 5-Fluorouracil Through Inhibition of NF-κB Activation. Asian Pac J Cancer Prev. 2018 Jan 27;19(1):49-56. [2]. Beni Lestari, et al. Pentagamavunon-1 (PGV-1) Inhibits ROS Metabolic Enzymes and Suppresses Tumor Cell Growth by Inducing M Phase (Prometaphase) Arrest and Cell Senescence. Sci Rep . 2019 Oct 16;9(1):14867.

盐酸克仑特罗 98%,分析标准品（剧毒品）  双(2-二苯基膦乙基)苯基磷 96%

盐酸克仑特罗 分析标准品，99.1%（剧毒品）  (1S,2S)-2-(二苯基膦)环己胺 97%

盐酸二甲双胍  97%  (1S,2S)-(-)-1, 2－二苯基－1, 2－乙二胺 98%

间二氯苄 97%  (1S,2S)-N-(对甲苯磺酰)-1,2-二苯基乙二胺 98%

液体石蜡 USP级  (1S,2S)-(+)-N,N'-二甲基环己烷-1,2-二胺 98%

甲基丙二酰氯 97%  (1S,2S)-(-)-1,2-?

NF 15710mg 50mg>98.00%Cas No. 104869-26-3C49H28F2N6Na6O23S6

NF 11010mg 50mg>98.00%Cas No. 111150-22-2C41H28N6Na4O17S4

DPO-110mg 50mg>98.00%Cas No. 43077-30-1C22H29OP

ICA 12143110mg 50mg>98.00%Cas No. 313254-51-2C23H19N3O3S2

Nelonicline (ABT-126)250mg 500mg>98.00%Cas No. 1026134-63-3C17H19N3OS

NNC 71110mg 50mg>98.00%Cas No. 145645-62-1C21H22N2O3.HCl

NNC 05-2090 hydrochloride10mg 50mg>98.00%Cas No. 184845-18-9C27H30N2O2.HCl