性能参数

产品名称

Paclitaxel octadecanedioate

规格

500μg 1mg 5mg 10mg

货号

GOY-Y2903

 含量

>98.00%

CAS

2089211-45-8

别名

N/A

化学名

N/A

分子式

C65H83NO17

分子量

分子量 1150.4

溶解度

DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 25 mg/ml,Ethanol: 20 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 μM. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner.

|1. Callmann, C.E., Leguyader, C.L.M., Burton, S.T., et al. Antitumor activity of 1,18-octadecanedioic acid-paclitaxel complexed with human serum albumin. J. Am. Chem. Soc. 141(30), 11765-11769 (2019).

1,2-二溴乙烷标准溶液100mg/L,溶剂:甲醇  四(三苯基膦)氢化铑(I) Rh 8.9% min

1,4-二溴丁烷 98%  (R,R)-2,2'-异亚丙基双(4-苯基-2-恶唑啉) 97%

3,5-二溴-4-羟基苯甲醛  95%  (S,S)-2,2'-异亚丙基双(4-苯基-2-恶唑啉) 97%

3,5-二溴-4-羟基苯甲醛  98%  (S,S)-(-)-2,2'-异亚丙基双(4-叔丁基-2-恶唑啉) 99%

氢溴酸 AR,40%  (-)2,2′-(3α，8α-二氢-8H-茚并[1，2--d?

L-364,37310mg 50mg>98.00%Cas No. 103342-82-1C25H20FN3O

KS 17610mg 50mg>98.00%Cas No. 1253452-78-6C22H19N3O5

KR-325681mg 5mg>98.00%Cas No. 852146-73-7C13H12FN3O2

KM 1106010mg 50mg>98.00%Cas No. 774549-97-2C19H17Cl2N3O2S

L-trans-2,4-PDC1mg 5mg>98.00%Cas No. 64769-66-0C6H9NO4

L-CCG-lll5mg 10mg>98.00%Cas No. 117857-95-1C6H9NO4