性能参数

产品名称

Z-IETD-FMK

规格

0mM (in 1mL DMSO) 1mg 5mg

货号

GOY-Y2858

 含量

>98.00%

CAS

210344-98-2

别名

Benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone, Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK

化学名

methyl 5-[[1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate

分子式

C30H43FN4O11

分子量

分子量 654.68

溶解度

≥ 32.734mg/mL in DMSO

储存条件

Store at -20° C

General tips

用途

仅供科研

价格

电询

详细内容

Z-IETD-FMK is an inhibitor of caspase 8 [1].

Z-IETD-FMK inhibits T cell proliferation induced by PHA or anti-CD3 plus anti-CD28 without toxicity of resting T cells. The mechanism of this inhibition of Z-IETD-FMK has been proved not through the effect on IL-2 secretion or IFN-γ production but the decrease of CD25 expression. Experiments show that Z-IETD-FMK has no effect on normal cell growth when there is no activation signal. Z-IETD-FMK has also been found to significantly inhibit NF-κB activation when the concentration is 100μM [1].

Apart from the ability of inhibiting cell proliferation, Z-IETD-FMK is reported to inhibit TRAIL-mediated killing in cells. It protects the procaspases 9, 2, and 3, and protects PARP to a similar extent in both HCT116 and SW480 cells [2].

氢氧化钙  ACS, ≥95.0%  季戊醇 AR,98.0%

钠石灰 医用级，红色  聚氯乙烯 K-value 68-65

钠石灰(带指示剂) ACS  聚氯乙烯 K-value 62-60

钠石灰 CP  氟硅酸钠 CP，97%

变色硅胶 LR  三羟甲基丙烷 98%

亚油酸  95%  6-姜烯酚 分析标准品，≥90%

ACET10mg>98.00%Cas No. 936095-50-0C20H19N3O6S

ACBC25mg>98.00%Cas No. 22264-50-2C5H9NO2

Amiloride (MK-870)100mg>98.00%Cas No. 2609-46-3C6H8ClN7O

AMG 216291 mg>98.00%Cas No. 939040-79-6C22H19F3N6O3

Arecaidine5mg>98.00%Cas No. 499-04-7C7H11NO2

Arcaine sulfate50mg>98.00%Cas No. 14923-17-2C6H16N6.H2SO4

AR-C 141990 hydrochloride1 mg>98.00%Cas No. N/AC26H28N4O4S.HCl