性能参数

产品名称

Temozolomide

规格

10mM (in 1mL DMSO) 10mg 50mg

货号

GOY-Y2842

 含量

>98.00%

CAS

85622-93-1

别名

N/A

化学名

3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

分子式

C6H6N6O2

分子量

分子量 194.15

溶解度

≥ 29.61mg/mL in DMSO

储存条件

Store at -20°C, protect from light, stored under nitrogen

General tips

用途

仅供科研

价格

电询

详细内容

Temozolomide (NSC 362856; CCRG 81045) is an oral DNA alkylating agent used to treat some brain cancers.

Temozolomide (TZM) is a methylating agent that crosses the blood-brain barrier and is indicated for malignant gliomas and metastatic melanomas. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system (MR)[1]. Determination of the IC50 for Temozolomide (TZM) in different cell lines gave values ranging from 14.1 to 234.6 μM that fell into two clearly differentiated groups: cell lines with low IC50 values (<50 μM), which include A172 (14.1±1.1 μM) and LN229 cells (14.5±1.1 μM), and those with high IC50 values (>100 μM), which include SF268 (147.2±2.1 μM) and SK-N-SH cells (234.6±2.3 μM)[2].

Temozolomide (TZM), as a single agent, does not significantly increase mdian survival time (MST) with respect to control. Noteworthy, intracranial injection of NU1025, immediately before the administration of 100 or 200 mg/kg Temozolomide, significantly increases lifespans with respect to controls or to groups treated with Temozolomide only. When Temozolomide is fractionated, the increase in lifespan (ILS) obtained with this schedule is higher than that observed when NU1025 is combined with a single injection of Temozolomide (statistical comparison of survival curves: NU1025 intracranially+Temozolomide 100 mg/kg×2 vs NU1025+Temozolomide 200 mg/kg; P=0.023)[1].

4-巯基吡啶  96%  钡 99.9% metals basis

2-苯基丁酸  99%  水质钡标样 浓度范围:0.834(mg/L)，分析标准品

苯基琥珀酸酐 99%  钡 99%

4-苯基吗啉  98%  硫酸铈,四水 AR，98%

(1S,2S,3R,5S)-(+)-2,3-蒎烷二醇 99%  硝酸铈，六水  99.95% metals basis

四氯化碲 99%  醋酸铈 99.9% metals basis

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