TAS-117 hydrochloride
如果您对该产品感兴趣的话,可以
产品名称:
TAS-117 hydrochloride
产品型号:
GOY-Y2839
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-04
简单介绍
TAS-117 hydrochlorideDMSO : 62.5 mg/mL (135.59 mM; ultrasonic and warming and heat to 60°C)
TAS-117 hydrochloride
的详细介绍
|
性能参数
|
|
产品名称
|
TAS-117 hydrochloride
|
|
规格
|
5 mg 10 mg 25 mg
|
|
货号
|
GOY-Y2839
|
|
含量
|
>98.00%
|
|
CAS
|
N/A
|
|
别名
|
N/A
|
|
|
|
化学名
|
N/A
|
分子式
|
C26H25ClN4O2
|
|
分子量
|
分子量 460.96
|
溶解度
|
DMSO : 62.5 mg/mL (135.59 mM; ultrasonic and warming and heat to 60°C)
|
|
储存条件
|
Store at -20°C
|
General tips
|
|
|
用途
|
仅供科研
|
价格
|
电询
|
|
|
|
详细内容
|
TAS-117 hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). TAS-117 hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. TAS-117 hydrochloride induces apoptosis and autophagy[1].
TAS-117 (1 μM; 6 hours) blocks basal phosphorylation of Akt and downstream p-FKHR/FKHRL1 in MM cells with high baseline p-Akt[1].TAS-117 (0-10 μM; 72 hours) selectively inhibits Akt and induces cytotoxicity in MM cells with high baseline phosphorylation of Akt[1].TAS-117 abrogates the cytoprotective effect of the bone marrow microenvironment associated with Akt inhibition in both MM cells and BMSCs. TAS-117 enhances Carfilzomib-induced cytotoxicity and fatal ER stress in MM cells. TAS-117 (0.5, 1 μM) triggers G0/G1 arrest followed by apoptosis, associated with induction of autophagy and endoplasmic reticulum stress response[1].TAS-117 enhances bortezomib-induced cytotoxicity, associated with increased CHOP (a fatal ER-stress marker) and PARP cleavage and blockade of bortezomib-induced p-Akt, suggesting that TAS-117 augments Bortezomib-induced ER stress and apoptotic signaling[1].
|
公司正在销售的产品：
|
3-甲氧基苯胺 98% 羧乙基锗倍半氧化物(GE 132) 99.95%
2-溴乙基乙酸酯 97% 锗 SP
**基溴硅烷, 含稳定剂铜, 98% 锗粉 99.999% metals basis，1mm
2-溴乙醇 96% 锗 Φ5mm 高2.5mm 锥形体 Ge≥99.999％
2-氯异烟酸 97% 锗 Φ7mm 高2.5mn 锥形体 Ge≥99.999％
克罗拉滨 99% 锗 4mm高(厚)1mm 圆柱体Ge≥99.999％
|
Dronedarone HCl10mM (in 1mL DMSO) 1g 5g>98.00%Cas No. 141625-93-6C31H45ClN2O5S
Epoxomicin1mg 5mg 20mg>98.00%Cas No. 134381-21-8C28H50N4O7
Fulvestrant (ICI 182,780)10mM (in 1mL DMSO) 25mg 100mg>98.00%Cas No. 129453-61-8C32H47F5O3S
Fluoxetine HCl10mM (in 1mL DMSO) 100mg 500mg>98.00%Cas No. 56296-78-7C17H18F3NO.HCl
Fluoxetine (LY-110140)50mg 100mg 500mg>98.00%Cas No. 54910-89-3C17H18F3NO
GLPG2451100mg 250mg 500mg>98.00%Cas No. 2055015-61-5C16H16F3N3O5S
Glaucocalyxin B10mM*1mLinDMSO 5mg 10mg>98.00%Cas No. 80508-81-2C22H30O5
|