性能参数

产品名称

Streptozocin

规格

10mM (in 1mL DMSO) 100mg 500mg

货号

GOY-Y2831

 含量

>98.00%

CAS

18883-66-4

别名

Streptozotocin; U 9889; STZ

化学名

1-methyl-1-nitroso-3-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea

分子式

C8H15N3O7

分子量

分子量 265.22

溶解度

≥ 10.3mg/mL in DMSO, ≥ 53.2mg/mL in H2O, ≥ 26.5mg/mL in EtOH with gentle warming

储存条件

4°C,

General tips

用途

仅供科研

价格

电询

详细内容

Streptozocin is a potent DNA-methylating antibiotic. Streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no methylation in brain DNA.

Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). ALX appeares not to be toxic for the studied cell lines with estimated IC50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60. The IC50 values of Streptozocin are 11.7, 904 and 1024 μg/mL for HL60, K562 and C1498 cells, respectively. Results also show that the murine leukemic cells are more resistant to Streptozocin and ALX cytotoxicity than human leukemic cells[2].

Streptozocin (STZ)-injected mice show tendency to have lower body weight than that observed in animals injected with ALX. Streptozocin -injected mice have significantly fewer splenocytes (22.2±3.2×106; n=10) compared to mice injected with ALX (60.7±4.3×106; n=15; p=0.01)[2].

2-庚酮 分析标准品,≥99.8% (GC)  钨 99.95%,12μm

2-庚酮 ≥98%, FCC, Kosher, FG  钨粉 9.95%,<1.1μm

羟基香草醛 98%  钨丝 99.95%，1mm 直径

羟基香草醛 98%,FCC  钨标准溶液 1000μg/ml

α-己基肉桂醛 92%  钨 3.5≤d＜5.0，99.95%

吲哚 99%  钨 99.95%，0.5mm 直径

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