性能参数

产品名称

S-trityl-L-Cysteine

规格

g 5g 10g

货号

GOY-Y2820

 含量

>98.00%

CAS

2799/7/7

别名

N/A

化学名

N/A

分子式

C22H21NO2S

分子量

分子量 363.5

溶解度

DMSO: slightly soluble,Methanol: 1 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective for Eg5 over nine other human kinesins in an enzyme-coupled assay. It reversibly inhibits Eg5-driven microtubule sliding velocity with an IC50 value of 500 nM using X. laevis recombinant Eg5. It induces cell cycle arrest in HeLa cells (IC50 = 700 nM), reversibly halting the cell cycle in the mitotic phase by inhibiting the separation of duplicated chromosomes and preventing bipolar spindle formation. S-trityl-L-Cysteine inhibits the growth of cancer cells in vitro when tested against the National Cancer Institute (NCI) 60 human cancer cell line panel (average GI50 = 1.3 μM) and in mouse xenograft models.

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4,4-双(4-羟苯基)戊酸 98.0 %  1,1,1-三氯乙烷 CP，96%

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