性能参数

产品名称

RIP1 kinase inhibitor 1

规格

100mg 250mg 500mg

货号

GOY-Y2810

 含量

>98.00%

CAS

2095515-38-9

别名

N/A

化学名

N/A

分子式

C24H20ClN5O3

分子量

分子量 461.9

溶解度

Soluble in DMSO

储存条件

4°C, away from moisture and light

General tips

用途

仅供科研

价格

电询

详细内容

RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1]. pKi: 9.04 (RIP1 kinase)[1]

RIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC50=15 nM; pMLKL, IC50=2.7 nM)[1].

[1]. Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, OrallyAvailable, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409.

硝酸钐 99.999% metals basis  水质铊标样 分析标准品（剧毒品）

硝酸钇,六水  AR，99.5%  1,2,4-三氯苯标准溶液 1000μg/ml,溶剂:甲醇

硝酸钇 99.9% metals basis  1,2,5-三氯苯标准溶液0.099mg/ml,溶剂:异辛烷

氯化钇,六水 99.99% metals basis  四氯化碳中石油类 (红外法)标样27.5-35-73.3mg/L

氯化钇(III) 六水合物 99.9% metals basis  1,2,4,5-四氯苯标准溶?

Ripasudil free base2mg 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 223645-67-8C15H18FN3O2S

ZINC0088152410mM*1mLinDMSO 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 557782-81-7C21H20N2O3S

ML32710mM*1mLinDMSO 1mg 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 1883510-31-3C19H18N4O4

Purity: >99.00%

(+)-Abscisic Acid-d61mg>99.00%Cas No. 721948-65-8C15H14D6O4

7α-hydroxy Cholesterol-d71mg>99.00%Cas No. 349553-94-2C27H39D7O2

Corynecin IV1mg>99.00%Cas No. 40958-11-0C13H16N2O6