PROTAC Mcl1 degrader-1
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产品名称:
PROTAC Mcl1 degrader-1
产品型号:
GOY-Y2794
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-28
简单介绍
PROTAC Mcl1 degrader-1DMSO: 50 mg/mL (54.95 mM)
PROTAC Mcl1 degrader-1
的详细介绍
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性能参数
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产品名称
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PROTAC Mcl1 degrader-1
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规格
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1mg 5mg 10mg
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货号
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GOY-Y2794
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含量
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>98.00%
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CAS
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2163793-38-0
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别名
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N/A
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化学名
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N/A
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分子式
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C45H45BrN6O8S
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分子量
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分子量 909.84
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溶解度
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DMSO: 50 mg/mL (54.95 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity[1].
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
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