性能参数

产品名称

Nigericin

规格

5mg 10mg 25mg

货号

GOY-Y2762

 含量

>98.00%

CAS

28380-24-7

别名

N/A

化学名

N/A

分子式

C40H68O11

分子量

分子量 724.96

溶解度

1.2mg/mL in DMF, 20mg/mL in Ethanol

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes[1].Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner[2]. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis[3].

[1]. Zotova L, et al. Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem. 2010 May 7;285(19):14399-414. [2]. Mariathasan S, et al.Cryopyrin activates the inflammasome in response to toxins and ATP.Nature. 2006 Mar 9;440(7081):228-32. [3]. Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118(5):381-9.

硫酸标准溶液 0.05000mol/L(0.1N)  丙烯醇 分析标准品（剧毒品）

无水硫酸钠 ACS, ≥99.0%  莰烯  分析标准品

无水硫酸钠 农残级  莰烯  75%

无水硫酸钠 for HPLC，≥99.0% (T)  莰烯  95%

无水硫酸钠 分析标准品， pestizides≤1 ppm  乙酸异龙脑酯 90%

无水硫酸钠 for plant cell culture, ≥99.0%  1,4-丁烯二醇（反式+顺式） 97%

Combretastatin A410mg 50mg>98.00%Cas No. 117048-59-6C18H20O5

CK 66610mg 50mg>98.00%Cas No. 442633-00-3C18H17FN2O

Chromomycin A21mg 5mg>98.00%Cas No. 6992-70-7C59H86O26

D-6413110mg 50mg>98.00%Cas No. 74588-78-6C16H13NO2

Cytochalasin J1mg 5mg>98.00%Cas No. 53760-20-6C28H37NO4

CYM 54781mg 5mg>98.00%Cas No. 870762-83-7C21H19F3N2O2

CW0692mg 5mg>98.00%Cas No. 1594094-64-0C23H21IN2O3