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Lysophosphatidylcholines

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产品名称: Lysophosphatidylcholines
产品型号: GOY-Y2737
产品展商: 谷研
产品文档: 无相关文档
发布时间:2023-04-28

简单介绍

LysophosphatidylcholinesSoluble in 2:1 solution of Chloroform : Methanol


Lysophosphatidylcholines  的详细介绍

性能参数

产品名称

Lysophosphatidylcholines

规格

10mg 25mg 50mg

货号

GOY-Y2737

 含量

>98.00%

CAS

9008-30-4

别名

?Lyso-Lecithins (egg)

 

 

化学名

N/A

分子式

C24H50NO7P (for palmitoyl)

分子量

分子量 495.6

溶解度

Soluble in 2:1 solution of Chloroform : Methanol

储存条件

Store at -20°C

General tips

 

用途

仅供科研

价格

电询

详细内容

Lysophosphatidylcholines are produced by hydrolysis of the fatty acid of phosphatidylcholine at either the sn-1 or sn-2 position by phospholipase A2 (PLA2) or by lecithin-cholesterol acyltranferase (LCAT), which transfers the fatty acid to cholesterol. [1] Lysophosphatidylcholine has effects on a variety of cell types, including smooth muscle cells, endothelial cells, T lymphocytes, monocytes, and macrophages among others. It is a major phospholipid component of oxidized low-density lipoprotein (ox-LDL), and it accumulates in animal models of atherosclerosis. Lysophosphatidylcholine also has pro-inflammatory properties through its activation and modulation of various signaling pathways, including the ERK pathway as well as through protein tyrosine kinase and G protein-coupled receptor (GPCR) signal transduction. It is released from apoptotic cells in vitro following caspase-3 activation of the calcium-independent PLA2 and acts as a chemoattractant for monocytes.[2]  Lysophosphatidylcholine (2 ul, 1%) injected into the caudal cerebellar peduncle of rats induces demyelination of axons in vivo, which are extensively remyelinated by oligodendrocytes six weeks following injection. [3] Lysophosphatidylcholines (egg) is a mixture of lysophosphatidylcholines isolated from chicken egg that has a fatty acid of variable chain length acylated to the sn-1 or sn-2 position.

 

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