性能参数

产品名称

Limonin

规格

 (in 1mL DMSO) 100mg 200mg

货号

GOY-Y2736

 含量

>98.00%

CAS

1180-71-8

别名

Limonoic acid 3,19:16,17 dilactone

化学名

12-(furan-3-yl)-6,6,8a,12a-tetramethyldecahydrooxireno[2,3-d]pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-3,8,10(1H,6H,8aH)-trione

分子式

C26H30O8

分子量

分子量 470.51

溶解度

≥ 23.9 mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Limonin is a chemically-induced carcinogenesis inhibitor and HIV-1 replication inhibitor.The human immunodeficiency virus (HIV) is a lentivirus that causes the acquired immunodeficiency syndrome (AIDS).

When culturing the HIV-1 in human peripheral blood mononuclear cells (PBMC) and monocytes/macrophages (M/M), Limonin inhibit the HIV-1 replication in all cellular systems and inhibit HIV-1 replication with EC50 value of 60u μM in PBMC cells in a dose-dependent way [1]. In human hepatoma HepG2 cells, limonin can induced apoptosis, which was evidenced by WB analysis of some apoptosis factors [2].

In the female Syrian hamsters treated with DMBA, which can cause tumor, limonin showed a 60% reduction in tumor burden. It decreased 20% tumor number and 50% tumor mass [3]. In male F344 rats treated with azoxymethane (AOM), 0.05% limonin in diet significantly reduced (65%-92% inhibition) the incidence of colonic adenocarcinoma. Thus, limonin has chemopreventive effects on chemically induced carcinogenesis [4].

溴化钾 ACS  镝标准溶液 1000μg/ml

酒石酸锑钾 99.99% metals basis   铕标准溶液  1000μg/ml

油酸钾 98%  铒标准溶液 1000μg/ml,基体:1.0 mol/L HNO₃

碳酸氢钾 ACS, 99.7-100.5% (dry basis)  铒标准溶液 1000μg/mL，基体：10%HCL

玫瑰红酸钠 AR  铕标准溶液 1000μg/mL in 10%HCL

玫瑰红酸钠 90%  甲醛标准溶液 1000μg/ml

RNPA100010mM*1mLinDMSO 2mg 5mg 10mg 50mg>98.00%Cas No. 359600-10-5C23H18BrN3O3

S/GSK134957210mM (in 1mL DMSO) 5mg 10mg 50mg 100mg>98.00%Cas No. 1051375-16-6C20H19F2N3O5

Secnidazole10mM (in 1mL DMSO) 10mg 50mg 100mg 500mg>98.00%Cas No. 3366-95-8C7H11N3O3

Sisunatovir hydrochloride5 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. 1903763-83-6C23H23ClF4N4O

Sisunatovir5 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. 1903763-82-5C23H22F4N4O