性能参数

产品名称

Z-WEHD-FMK

规格

20 μl (10 mM) 100 μl (2 mM)

货号

GOY-Y2733

 含量

>98.00%

CAS

210345-00-9

别名

Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone)

化学名

methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoate

分子式

C37H42FN7O11

分子量

分子量 763.78

溶解度

N/A

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Treatment of infected cells with pan-caspase inhibitor IV and Z-WEHD-FMK, an inhibitor of inflammatory caspases, elicited a near-complete blockage of C. trachomatis-induced cleavage of golgin-84. Golgin-84 cleavage was blocked via treatment of infected cells with Z-WEHD-FMK, resulting in a lack of Golgi fragmentation and a 2-log reduction in numbers of infectious bacteria.

We treated infected cells with Z-WEHD-FMK, effectively preventing Golgi fragmentation, or with DMSO as a control and then labelled cells with fluorescent ceramide. Confocal images revealed that ceramide was rapidly incorporated into the inclusion membrane within DMSO-treated cells and accumulated inside the inclusion in bacterial membranes. In contrast, Z-WEHD-FMK-treated cells were only slightly fluorescent as the majority of lipid accumulated in a Golgi-like structure outside the inclusion1.

General caspase inhibitor (Z-Asp-CHz-DCB) and capase-5 inhibitor (Z-WEHD-FMK) could not induce rRNA fragmentation treated with ECyd. Caspase-5 (ICErei Ill/TY), member of ICE protease, activated pathway may be concerned with ECyd induced rRNA fragmentation2.

溴化钾 AR,99.0%  镉标准溶液 1000μg/ml，溶剂：1%硝酸

溴化钾 CP,98.0%      镉标准溶液 100mg/L，溶剂：1%硝酸

溴化钾 GR  镉标准溶液100ug/mL，基体: 1%硝酸

溴化钾 光谱纯SP  镉标准溶液0.100μg/g，基体:K+ 2.2mg/L,Na+ 23mg/L,Ca2+ 39mg/L

溴化钾 99.95% metals basis，无水级，粉末  钴标准溶液 1000μg/ml

溴化钾 99.99% metals basis  钴标准溶液 500m?

Presatovir (GS-5806)10mM*1mLinDMSO 5mg 10mg 50mg 100mg>98.00%Cas No. 1353625-73-6C24H30ClN7O3S

Potassium clavulanate cellulose10mg 50mg 100mg 200mg 500mg>98.00%Cas No. N/AC8H9NO5K .(C6H10O5)n

PSI-6206 13CD31mg 5mg 10mg 50mg 100mg>98.00%Cas No. 1256490-42-2C9(13C)H10D3FN2O5

PSI-620610mM (in 1mL DMSO) 5mg 10mg 25mg 50mg>98.00%Cas No. 863329-66-2C10H13FN2O5

PSI-613010mM*1mL in DMSO 2mg 5mg 10mg 50mg>98.00%Cas No. 817204-33-4C10H14FN3O4