性能参数

产品名称

Tubulysin B

规格

1mg 5mg

货号

GOY-Y2725

 含量

>98.00%

CAS

205304-87-6

别名

N/A

化学名

N/A

分子式

C42H63N5O10S

分子量

分子量 830.04

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.

[1]. Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813. [2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.

结晶碳酸钾 99.99% metals basis  3-苯丙酸 GR，99%

结晶碳酸钾 ACS  3-苯丙酸 CP，98%

亚铁钾,三水 ≥99.99% metals basis  惕格酸 98%

亚铁钾,三水 ACS, 98.5-102.0%  惕格酸 Kosher, ≥98%, FG

亚铁钾,三水 AR，99.0%  桃醛 98%

氟钛酸钾 CP,99.0%  γ-戊内酯 98%

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