性能参数

产品名称

Tubulysin H

规格

1mg 5mg

货号

GOY-Y2720

 含量

>98.00%

CAS

799822-09-6

别名

N/A

化学名

N/A

分子式

C40H59N5O9S

分子量

分子量 785.99

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Tubulysin H is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. Tubulysin H is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[3].

[1]. Steinmetz H, et al. Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria. Angew Chem Int Ed Engl. 2004 Sep 20;43(37):4888-92. [2]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. [3]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.

过硫酸钾 99.99% metals basis  水杨醇 98%

硫氰酸钾 AR,98.5%  苯甲酸钾 AR,99.0%

硫氰酸钾 CP,98%  苯甲酸苯酯 99%

硫氰酸钾 GR,99%  苯甲酸钠 AR,99.5%

硫氰酸钾 ACS  苯甲酸钠 药用级

硫氰酸钾标准溶液 0.1000mol/L(0.1N)  邻甲苯甲酸 98%

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Pirodavir2mg 5mg 10mg 50mg>98.00%Cas No. 124436-59-5C21H27N3O3

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Polyoxyethylene stearate (POES)10mM*1mLinDMSO 200mg 1g 5g>98.00%Cas No. 9004-99-3C20H40O3

Polymyxin B nonapeptide5mg 10mg 50mg 100mg>98.00%Cas No. 86408-36-8C43H74N14O11