性能参数

产品名称

Tubulysin M

规格

1mg 5mg

货号

GOY-Y2718

 含量

>98.00%

CAS

936691-46-2

别名

N/A

化学名

N/A

分子式

C38H57N5O7S

分子量

分子量 727.95

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Tubulysin M is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. Tubulysin M is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[3].

[1]. Wang Y, et al. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules. Mol Pharmacol. 2016 Feb;89(2):233-42. [2]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. [3]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.

重铬酸钾 GR,99.8%  苯甲腈 CP,98.5%

重铬酸钾 PT  苯甲腈 >99% (GC)

重铬酸钾 SP  苯甲酰氯 AR,99.0%

重铬酸钾 99.99% metals basis  苯甲酰氯 ACS, ≥99.5% (T)

重铬酸钾 ACS, ≥99.0%  苯甲醇 CP,98%

重铬酸钾 分析标准品，99.998%  苄胺 AR,99.00%

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