性能参数

产品名称

Triglycidyl isocyanurate

规格

10mM*1 mL in DMSO 500mg

货号

GOY-Y2717

 含量

>98.00%

CAS

2451-62-9

别名

N/A

化学名

N/A

分子式

C12H15N3O6

分子量

分子量 297.26

溶解度

DMSO: 50 mg/mL (168.20 mM)

储存条件

Store at 4°C

General tips

用途

仅供科研

价格

电询

详细内容

Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2].

Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1].Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Cell Viability Assay[1] Cell Line: A549, H460 and H1299 cells

Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2-3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice[2]. Animal Model: Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area[2]

[1]. Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143 [2]. Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008

高氯酸 ACS, ≥69% (T)  阿斯巴甜 98%

氯化钾 ≥99.99% metals basis  碳酸镉 AR,98%

氯化钾 分子生物学专用, ≥99.5%  碳酸镉 CP,97%

氯化钾 细胞培养专用, ≥99.5%  碳酸镉 99.99%

重铬酸钾 AR,99.8%  苯甲酸铵 CP,98.0%

重铬酸钾 CP，99.5%  苯甲酸苄酯  >99.0%(GC)

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WQ 27431mg 5mg 10mg>98.00%Cas No. 189280-13-5C19H15BrF3N5O3

Walrycin B5mg 10mg 50mg>98.00%Cas No. 878419-78-4C14H10F3N5O2

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