性能参数

产品名称

TAME

规格

50mg 200mg

货号

GOY-Y2707

 含量

>98.00%

CAS

901-47-3

别名

N/A

化学名

methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate

分子式

C14H22N4O4S

分子量

分子量 342.41

溶解度

≥ 17.1mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

TAME (Tosyl-L-Arginine Methyl Ester) is a small molecule APC (Anaphase-promoting complex/cyclosome) inhibitor with IC50 of 12 μM in Xenopus oocytes. [1]

APC is an ubiquitin ligase with multi subunits. It ubiquitinates substrates (e.g. cyclin B1 and secrin) and make them the targets for degradation with 26s proteasome, resulting in initiation of anaphase and mitotic exit. [2]

In mitotic Xenopus oocytes, TAME competes with the Cdc20 C-terminal IR-tail for APC binding to inhibit APC-dependent proteolysis. [3] TAME also stabilizes cyclin B1via terminating ubiquitination prenaturally. It slows the unmodified cyclin B1 initial ubiquitination. In the presence of TAME, ubiquitinated cyclin B1 is not able to promote Cdc20 binding to the APC. [4]

磷酸二氢钾 99.99% metals basis  1,2-乙二硫醇 97%

磷酸三钾 AR  溴代异辛烷 99%

邻苯二甲酸 CP,99.0%  薄荷酰胺 98%

邻苯二甲酸 ACS, ≥99.5%  1-己硫醇 96%

邻苯二甲酸 AR,99.5%  正庚硫醇 98%

邻苯二甲酸 standard for GC, ≥99.5% (GC)  1,6-己二硫醇 97%

Sofosbuvir impurity K10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. 1496552-51-2C22H29ClN3O9P

Sofosbuvir impurity I10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. N/AC21H27FN3O9P

Sofosbuvir impurity H10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. N/AC29H33FN3O10P

Sofosbuvir impurity G10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. 1337482-15-1C22H29FN3O9P

Sofosbuvir impurity F10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. 1337482-17-3C34H45FN4O13P2

Sofosbuvir impurity E10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. N/AC22H29FN3O9P