性能参数

产品名称

Streptochlorin

规格

1mg 5mg

货号

GOY-Y2705

 含量

>98.00%

CAS

120191-51-7

别名

N/A

化学名

N/A

分子式

C11H7ClN2O

分子量

分子量 218.6

溶解度

DMSO: soluble,Methanol: soluble

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).

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油酸钾 CP  1,3-二溴丙烷 98%

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