性能参数

产品名称

Salinomycin sodium salt

规格

100mg 50mg

货号

GOY-Y2684

 含量

>98.00%

CAS

55721-31-8

别名

Salinomycin sodium;Sodium salinomycin

化学名

sodium;2-[6-[6-[3-(5-ethyl-5-hydroxy-6-methyloxan-2-yl)-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoate

分子式

C42H69NaO11

分子量

分子量 773.99

溶解度

DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 5 mg/ml,Ethanol: 10 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment)

Salinomycin (Sal) sodium salt, which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, or other pathways.

In vitro: Several hepatocellular carcinoma (HCC) cell lines were treated with Sal. Results showed that Sal inhibited proliferation and decreased PCNA levels. Cell cycle analysis showed that Sal caused cell cycle arrest in different phases. Sal induced apoptosis as characterized by an increase in the Bax/Bcl-2 ratio. Compared to control, β-catenin expression was down-regulated by Sal treatment significantly. The Ca2+ concentration in HCC cells was examined by flow cytometry and it was found that higher Ca2+ concentrations were observed in Sal treatment groups [1].

In vivo: The in vivo anti-tumor effect of Sal was verified using the hepatoma orthotopic tumor model and results showed that the liver tumor size in Sal-treated groups decreased. Immunohistochemistry and TUNEL staining also demonstrated that Sal could in vivo inhibit proliferation and induced apoptosis [1].

Clinical trial: N/A

硝酸镁,六水 AR，99%  硝酸银标准溶液 0.1017mol/L

硝酸镁,六水 CP，98%  硫酸根离子标准溶液100μg/ml,基体:硫酸钠溶液

硝酸镁,六水 SP  硫酸根离子标准溶液1000μg/ml,溶剂:水

硝酸镁,六水 ACS  硫酸根离子标准溶液100μg/ml,溶剂:水

硝酸镁,六水 99.99% metals basis  硫化物标准溶液 硫离子：50～100μg/mL

硝酸镁,六水 99.999% metals basis   草酸钠标准溶液容量分析用,0.1000m?

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