性能参数

产品名称

Rilmenidine

规格

10mg 5mg

货号

GOY-Y2683

 含量

>98.00%

CAS

54187-04-1

别名

N/A

化学名

N/A

分子式

C10H16N2O

分子量

分子量 180.25

溶解度

DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:6): 0.14 mg/ml

储存条件

N/A

General tips

用途

仅供科研

价格

电询

详细内容

Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation[2]. Cell Viability Assay[2] Cell Line: K562 cells

Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age[3].

[1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. [2]. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180. [3]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.

硼酸铅 CP,98.0%  草酸钠 分析标准品，99.96%

硫酸铅 AR,98.0%  硫标准溶液 1000ug/ml，基体:1%HCl

硫酸铅 CP,97.0%  糖精钠标准溶液 1.00mg/mL，基体：纯水

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碳酸铅 99.99% metals basis  1000μg/mL，基体：10%HCL

溴化铅 99.999% metals basis  100mg/L(20&#?

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