性能参数

产品名称

Polygalacin D

规格

1mg 5mg

货号

GOY-Y2669

 含量

>98.00%

CAS

66663-91-0

别名

N/A

化学名

N/A

分子式

C57H92O27

分子量

分子量 1209.32

溶解度

Soluble in DMSO

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]

Polygalacin D (0-40 μM; 48 hours) inhibits cell proliferation with IC50s of 26.49 μM in the A549 cells and 20.52 μM in the H460 cells[1].Polygalacin D (0-20 μM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1].Polygalacin D (0-20 μM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1]. Cell Proliferation Assay[1] Cell Line: A549 and H460 cancer cell lines

[1]. Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr;39(4):1702-1710.

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